Dr Sarah Martin
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Research InterestsSarah is a research fellow at KPF with expertise in mass spectrometry-based proteomics, quantification, statistical analysis, project and data management. Her research interests focus on the development of novel assays and methods to maximise the extraction of knowledge from data. She has published techniques to quantify protein turnover by mass spectrometry (Martin et al 2012, Le Bihan et al 2011), in silico assessments of the coverage of the human proteome by mass spectrometry (Le Bihan et al 2010) and an appraisal of challenges and good practice in proteomic data analysis (Martin et al 2013).
KPF Projects and CollaborationsSarah leads a number of internal and external research projects including nutrient deprivation of picoplankton (KPF), phosphorylation signatures in circadian rhythms (van Ooijen et al 2013), extremophile bacteria cultured in rock cultures (Cockell Lab, UK Centre for Astrobiology), viral infection of macrophages (Ghazal Lab, Pathway Medicine), bacteroides fragilis vesicle signalling (Blakely Lab, Biological Sciences), sperm surface proteins and defensins (Dorin Lab, Human Genetics Unit) and accute liver failure biomarkers (Hepatology, Edinburgh Royal Infirmary).
She also inputs into further projects, particularly with data analysis and statistics, including models of ischemic stroke (James et al 2011), clinical glioblastoma proteomics (Deighton Lab, Biomedical Sciences) and proteogenomic profiling of the picoalga Ostreococcus tauri (KPF). |
SkillsSarah particularly enjoys projects that require a cross-disciplinary and resourceful technical approach and rigorous analysis.
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TeachingSarah lectures in systems biology and mass spectrometry at undergraduate and postgraduate levels and has devised laboratory classes for first year physics teaching and a mystery samples biology activity for school visits. She also supervises undergraduate, summer and PhD projects. Sarah is passionate about evidence-based science and education, volunteering at Researchers in Residence, Physics in the Field, Lab in a Lorry, National Science Week and the Edinburgh Science Festival.
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Background
Sarah is a truly interdisciplinary scientist. With an MSci in natural sciences (theoretical and experimental physics) from Newnham College, Cambridge (2004), she initially worked on organic semiconductors, gaining a fellowship to study polymers for use in solar cells at the RIKEN Institute in Wako-shi, Japan. She then completed her PhD at the University of St Andrews (2008) using optical physics methods in protein science, working in both spectroscopy and molecular biology labs and collaborating with medical researchers. As a postdoc at the University of Edinburgh, she moved further into life sciences, working in a small team in a start-up mass spectrometry lab, where she applied skills ranging from cell culture through to statistical programming, gaining a British Society for Proteome Research fellowship in 2010 and being shortlisted for the Young Investigator Award in the same year.
She co-convened the School of Biological Sciences Press Gang 2008-2012 and set up and chaired the school's research staff society BioDocSoc 2009-2011. Sarah was selected to participate in the leadership programs Scottish Crucible 2011 and InGenious 2012.
She co-convened the School of Biological Sciences Press Gang 2008-2012 and set up and chaired the school's research staff society BioDocSoc 2009-2011. Sarah was selected to participate in the leadership programs Scottish Crucible 2011 and InGenious 2012.
Selected Publications
2013
S.F. Martin, H. Falkenberg, T.F. Dyrlund, G.A. Khoudoli, C.J. Mageean, R. Linding:
PROTEINCHALLENGE: Crowd sourcing in proteomics analysis and software development.
Journal of Proteomics 88: 41-46.
2012
S.F. Martin, V.S. Munagapati, E. Salvo-Chirnside, L.E. Kerr, T. Le Bihan:
Proteome Turnover in the Green Alga Ostreococcus tauri by Time Course (15)N Metabolic Labeling Mass Spectrometry.
Journal of proteome research 11: 476–486.
2011
T. Le Bihan, S.F. Martin, E.S. Chirnside, G. van Ooijen, M.E. Barrios-Llerena, J.S. O'Neill, P.V. Shliaha, L.E. Kerr, A.J. Millar:
Shotgun proteomic analysis of the unicellular alga Ostreococcus tauri.
Proteomics 74: 2060–2070.
R. James, J.L. Searcy, T. Le Bihan, S.F. Martin, C.M. Gliddon, J. Povey, R.F. Deighton, L.E. Kerr, J. McCulloch, K. Horsburgh:
Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge.
Journal of Cerebral Blood Flow and Metabolism 32: 164–176.
2010
T. Le Bihan T, R. Grima, S.F. Martin, T. Forster, Y. Le Bihan
Quantitative analysis of low-abundance peptides in HeLa cell cytoplasm by targeted liquid chromatography/mass spectrometry and stable isotope dilution: emphasising the distinction between peptide detection and peptide identification.
Rapid Communications in Mass Spectrometry 24: 1093–1104.
2008
S.F. Martin, Tatham MH, Hay RT, Samuel IDW:
Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway.
Protein Science 17: 777–784.
2007
S.F. Martin, Hattersley N, Samuel IDW, Hay RT, Tatham MH.
A fluorescence-resonance-energy-transfer-based protease activity assay and its use to monitor paralog-specific small ubiquitin-like modifier processing.
Analytical Biochemistry 363: 83–90.
S.F. Martin, A.D. Wood, M.M. McRobbie, M. Mazilu, M.P. McDonald, I.D.W. Samuel, S.C. Herrington:
Fluorescence spectroscopy of an in vitro model of human cervical precancer identifies neoplastic phenotype.
International Journal of Cancer 120: 1964–1970.
S.F. Martin, H. Falkenberg, T.F. Dyrlund, G.A. Khoudoli, C.J. Mageean, R. Linding:
PROTEINCHALLENGE: Crowd sourcing in proteomics analysis and software development.
Journal of Proteomics 88: 41-46.
2012
S.F. Martin, V.S. Munagapati, E. Salvo-Chirnside, L.E. Kerr, T. Le Bihan:
Proteome Turnover in the Green Alga Ostreococcus tauri by Time Course (15)N Metabolic Labeling Mass Spectrometry.
Journal of proteome research 11: 476–486.
2011
T. Le Bihan, S.F. Martin, E.S. Chirnside, G. van Ooijen, M.E. Barrios-Llerena, J.S. O'Neill, P.V. Shliaha, L.E. Kerr, A.J. Millar:
Shotgun proteomic analysis of the unicellular alga Ostreococcus tauri.
Proteomics 74: 2060–2070.
R. James, J.L. Searcy, T. Le Bihan, S.F. Martin, C.M. Gliddon, J. Povey, R.F. Deighton, L.E. Kerr, J. McCulloch, K. Horsburgh:
Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge.
Journal of Cerebral Blood Flow and Metabolism 32: 164–176.
2010
T. Le Bihan T, R. Grima, S.F. Martin, T. Forster, Y. Le Bihan
Quantitative analysis of low-abundance peptides in HeLa cell cytoplasm by targeted liquid chromatography/mass spectrometry and stable isotope dilution: emphasising the distinction between peptide detection and peptide identification.
Rapid Communications in Mass Spectrometry 24: 1093–1104.
2008
S.F. Martin, Tatham MH, Hay RT, Samuel IDW:
Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway.
Protein Science 17: 777–784.
2007
S.F. Martin, Hattersley N, Samuel IDW, Hay RT, Tatham MH.
A fluorescence-resonance-energy-transfer-based protease activity assay and its use to monitor paralog-specific small ubiquitin-like modifier processing.
Analytical Biochemistry 363: 83–90.
S.F. Martin, A.D. Wood, M.M. McRobbie, M. Mazilu, M.P. McDonald, I.D.W. Samuel, S.C. Herrington:
Fluorescence spectroscopy of an in vitro model of human cervical precancer identifies neoplastic phenotype.
International Journal of Cancer 120: 1964–1970.